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OTU deubiquitinases use four distinct mechanisms of linkage specificity to hydrolyze ubiquitin, and, due to their specificity, OTU DUBs can be used in ubiquitin ...
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Mar 23, 2023 · The Toxoplasma genome encodes all the necessary components for the ubiquitin–proteasome system including one E1 enzyme, 13–16 predicted E2- ...
Dec 28, 2019 · Abstract. Post-translational modification of cellular proteins by ubiquitin regulates numerous cellular processes, including cell division, ...
Aug 29, 2010 · OTU domain deubiquitinases hydrolyze polyubiquitin chains, yet some members show remarkable selectivity between Lys48 and Lys63 linkages. A20 ...
Feb 24, 2022 · Here we present deubiquitinase-targeting chimeras (DUBTACs), heterobifunctional small molecules consisting of a deubiquitinase recruiter linked ...
OTU‐family deubiquitinases (DUBs) regulate human ubiquitin signaling and have been subverted by viruses, while their use by pathogenic bacteria remains less‐ ...
OTU domain-containing ubiquitin aldehyde-binding proteins Otubain1 (OTUB1) and Otubain2 (OTUB2) were initially identified as OTU deubiquitinases (DUBs).
Linear ubiquitin chains can be hydrolyzed by the DUBs. “OTU DUB with linear linkage specificity” (OTULIN). [43,44] and Cylindromatosis (CYLD) (Fig. 3A,B). [45, ...
Nov 13, 2020 · A novel class of bacterial OTU deubiquitinases provides insights on the distinct roles of bacterial deubiquitinases in host–pathogen ...
DUBs often contain a catalytic · The catalytic domain of DUBs is what classifies them into particular groups; USPs, OTUs, MJDs, UCHs and MPN+/JAMMs. The first 4 ...